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(AdCa ): Adenocarcinoma: A tumor which does not fit into the Dunn criteria and is forming glands and has no other specific characteristics.
(Dunn): Dr. Thelma Dunn thoroughly described and classified the "spontaneous" mammary tumors of mice. About 93% of all MuMTV-induced mammary tumors are either Type A or Type B. Type A tumors have a microacinar pattern. Type B tumors have a solid cord-like pattern. Interestingly enough, wnt-1 tumors resemble the Type A tumors and int-2 tumors resemble the Type B tumors. Previous studies indicate that the virus activates these two oncogenes.
(KA):Keratoacanthoma: A tumor of mice that has a combination of gland and squamous differentiation. These tumors often produce enormous quantities of keratin. They frequently have squamous pearls.
(LC):The Large Cell Tumors are related to the myc transgene. These tumors have very large nuclei with course, clumped hyperchromatic chromatin and dark, amphophilic cytoplasm. They generally form glands.
(NOD):Nodular tumors: Composed of solid nests of cells with peripheral pallisades of cells. The cells tend to be intermediate between the large cell of myc and small cell of ras associated tumors. The nodular intermediate cell tumor is characteristic of neu and neu-related tumors(19, Neu). Since these tumors tend to present as ductal masses with necrosis, they sometimes have central necrosis, providing a comedo patternand resemblehuman DCIS.
(NOD): The nodular or intermediate cell tumors are related to the neu transgene. They are composed of cells with nuclei intermediate in size between the large myc type cell and the smaller ras type tumor. The chromatin is course and the cytoplasm tends to be pale pink with rigid cell membranes. Nodular tumors have solid nests of cells and tend to have a peripheral pallisade of tumor cells.
(NOS): Not Otherwise Specified. These are generally conditions or tumors that do not fit into any convenient group or category.
(PAP):Papillary Carcinoma: These tumors have finger-like projections with central fibrovascular stalks covered by an epithelium. These tumors are common in Polyoma Virus Wild Type Middle T transgenic mice.
(SmC):The Small Cell papillary Carcinomas are typical of the ras transgene. These tumors generally have small uniform cells with red cytoplasm and are organized in a papillary array.
Sarcoma: Sarcomas of the mammary gland are relatively rare. They have no epithelium. The commonest sarcoma is the hamangiosarcoma found in assocation with p53 knockout mice.
(ScCa): Scirrhous Carcinoma: A mammary tumor with a dense connective tissue. These tumors appear most frequently in the mice with activated src or Polyoma Middle T and its varients. These tumors are interesting because they closely resemble the scirrhous carcinomas found in humans.
(SqCa):Squamous Cell Carcinoma: A relatively rare diagnosis for mouse mammary tumors. It is used to indicate that the tumor has a purely squamous cell differentiation with no glandular elements.