COMBINATIONS OF TRANSGENES AND KNOCKOUTS


The following table records the incidence of mammary tumors in combinations of transgenes and/or knockouts in the archives of the U.C.D. Department of Medical Pathology Transgenic Pathology Laboratory from 1990 through 1997. 
The Genotypes are linked to the OMIM site for identification and narrative. The brackets are linked to bibliography. The Phenotype refers to the histological type and are linked to definitions and/or prototype images. These images can be compared on the Key page. The written glossary can be found by clicking here.
GENOTYPE Mice Tumors LC NOD SmC PAP ACa KA SqCa ScCa Dunn NOS Sarcoma Lym
ataxia telxp21 2 3 0 0 2 0 0 0 0 0 0 0 1 0
ataxia telxp53 7 12 1 0 0 0 0 0 0 0 0 1 10 0
ataxia telxRARE 1 1 0 0 0 0 0 0 0 0 0 0 0 1
cas.kinasexp53 5 5 1 0 1 0 0 0 0 0 0 0 3 0
cyclinD1-xp53(WT) 4 7 0 0 0 0 5 2 0 0 0 0 0 0
cyclinD1xMMTV 9 10 0 0 0 0 0 2 0 1 7 0 0 0
cyclinD1xp53 1 1 0 0 0 0 0 0 0 0 0 0 1 0
cyclinD1xp53 1 1 0 0 0 0 0 0 0 0 0 0 1 0
cyclinD1xp53 3 10 0 0 0 1 3 5 0 0 0 1 0 0
cyclinD1xp53(WT) 1 3 0 0 0 0 0 0 0 0 0 1 2 0
ephos kinasexp53 2 5 0 0 0 0 4 0 0 0 0 0 1 0
int2xint1 1 2 0 0 0 0 0 0 0 0 2 0 0 0
int2xp53 10 16 0 1 0 1 8 1 0 0 0 1 4 0
JNKAPFxHerg 1 7 0 0 0 0 0 7 0 0 0 0 0 0
mycxBrCa1 4 5 5 0 0 0 0 0 0 0 0 0 0 0
mycxcas.kinase 10 11 11 0 0 0 0 0 0 0 0 0 0 0
mycxephos 2 4 4 0 0 0 0 0 0 0 0 0 0 0
mycxherg 14 28 22 0 0 0 6 0 0 0 0 0 0 0
mycxIL4 KO 2 2 0 0 1 0 1 0 0 0 0 0 0 0
mycxp21 8 12 10 1 0 0 0 0 0 0 0 0 0 1
mycxp53 48 50 30 1 0 0 0 0 0 0 0 1 0 18
neu mutxShc3 1 2 0 2 0 0 0 0 0 0 0 0 0 0
neu mutxwaved2 4 8 0 8 0 0 0 0 0 0 0 0 0 0
neuxBrCa1 5 9 0 9 0 0 0 0 0 0 0 0 0 0
neuxephosKO 11 23 0 9 0 0 0 0 0 0 0 14 0 0
neuxp21 KO 27 55 0 55 0 0 0 0 0 0 0 0 0 0
neuxp53 32 43 1 20 0 2 19 0 0 0 0 1 0 0
neuxras 1 1 0 0 0 0 1 0 0 0 0 0 0 0
neuxTGFa 24 43 0 26 0 9 7 0 1 0 0 0 0 0
neuxwaved2 4 4 0 0 0 0 4 0 0 0 0 0 0 0
PyV-MT250xshc3 1 1 0 0 0 0 0 0 0 0 0 1 0 0
PyV-MTxLTN 2 2 0 0 0 1 1 0 0 0 0 0 0 0
PyV-Mtxmmtv 6 6 0 0 0 0 5 0 0 0 0 1 0 0
PyV-Mtxsrc-/- 11 11 0 0 0 1 4 5 0 1 0 0 0 0
PyV-Mtxyes 53 53 0 0 0 21 17 2 0 13 0 0 0 0
PyV-Mtxyes-/- 4 4 0 0 0 4 0 0 0 0 0 0 0 0
rarexp53 2 2 0 0 0 0 0 0 0 0 0 0 1 1
rasxIL4 KO 10 10 0 0 2 2 3 0 0 0 2 0 0 1
rasxIL7 1 1 0 0 0 0 1 0 0 0 0 0 0 0
rasxp21 1 1 0 0 1 0 0 0 0 0 0 0 0 0
rasxp53 15 18 0 1 1 2 1 0 0 0 7 4 2 0
rasxrare 1 2 0 0 0 0 0 0 0 0 0 2 0 0
wnt10xTGFb 6 10 0 0 0 0 0 2 0 0 8 0 0 0
TOTALS= 358 504 85 133 8 44 90 26 1 15 26 28 26 22
The following table is a summary of the transgenic animals with either two transgenes or a transgene and a knock out from 1990 through 1997. 
Mice Tumors LC NOD SmC PAP ACa KA SqCa ScCa Dunn NOS Sarcoma Lym
TOTAL 358 504 85 133 8 44 90 26 1 15 26 28 26 22
MAMMARY TUMORS= 358
NUMBER OF TRANSGENE COMBINATIONS= 43  
Back to Mammary Biology Page
Grand Summary Table
One Gene Table

Last Update: 7/22/98

Name: Medical Pathology

Email: rdcardiff@ucdavis.edu