40, 41, 68, 42. LOBULAR CARCINOMA-IN-SITU

LEGEND

SlideS 40, 41, 68 and 42. The image on the far left is a subgross photograph of carcinoma-in-situ of the lobular cytological type (lobular-carcinoma-in-situ, or LCIS , or lobular neoplasia). LCIS typically consists of poorly defined, enlarged lobules as seen here. This group of four lobules measures about 1.5 x 1.0 mm. Note the poorly defined enlarged acini filled with cells. The left middle image is a histological preparation showing the typical cells of LCIS completely filling distended acini. The right middle image reveals LCIS cells replacing cells of a normal duct. The image to the far right is of the likely preneoplastic lesion for LCIS. The acini in this instance are not distended by the atypical cells, and luminal space remains. This appearance is traditionally called "atypical lobular hyperplasia". We refer to this lesion as ALB (atypical lobules, type B) in order to distinguish them from the more common ALA (atypical lobules, type A). Hematoxylin stain.

40, 41, 68, 42. LOBULAR CARCINOMA-IN-SITU

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