*602041 HOMEO BOX 3A, NK; NKX3A
NKX3.1, MOUSE, HOMOLOG OF
NK HOMEO BOX, FAMILY 3, MEMBER A
Gene Map Locus: 8p21
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Using a random cDNA sequencing approach, He
et al. (1997) cloned a novel prostate-specific gene that encodes
a homeo box-containing protein.
The gene, symbolized NKX3.1 by them, encodes a 234-amino acid polypeptide
with greatest homology to the Drosophila NK-3 gene.
He et al. (1997) used fluorescence in situ
hybridization to map the NKX3.1 gene to human chromosome 8p21.
Northern blots showed that NKX3.1 had a uniquely restricted tissue
expression pattern.
The 3.5-kb NKX3.1 mRNA was abundant in the prostate, present at a
lower level in the testis, and absent from all other tissues tested.
He et al. (1997) detected NKX3.1 expression
in a hormone-responsive, androgen receptor-positive prostate cancer
cell line, but not in either of 2 androgen receptor-negative prostate
cancer cell lines, nor in 11 other cell lines of varied origin.
Androgen stimulation markedly increased NKX3.1 expression in an androgen-dependent
carcinoma line.
He et al. (1997) stated that the chromosomal
region to which the gene maps is frequently reported to undergo loss
of heterozygosity during the progression of prostate cancer.
They suggested that the NKX3.1 gene plays a role in androgen-driven
differentiation of prostatic tissue and in the loss of that differentiation
during the progression of prostate cancer.
Bieberich et al. (1996) cloned and characterized
Nkx3.1, the mouse homolog of this gene.
See also 602183, the
human homolog of Nkx3.2.
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1. Bieberich, C. J.; Fujita, K.; He, W. W.; Jay, G. :
- Prostate-specific
and androgen-dependent expression of a novel homeobox gene.
J. Biol. Chem. 271: 31779-31782, 1996.
PubMed ID : 8943214
-
2. He, W. W.; Sciavolino, P. J.; Wing, J.; Augustus, M.; Hudson, P.;
Meissner, P. S.; Curtis, R. T.; Shell, B. K.; Bostwick, D. G.; Tindall,
D. J.; Gelmann, E. P.; Abate-Shen, C.; Carter, K. C. :
- A
novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1)
that maps to 8p21, a region frequently deleted in prostate cancer.
Genomics 43: 69-77, 1997.
PubMed ID : 9226374
Victor A. McKusick - updated : 12/14/1997
Jennifer P. Macke : 10/9/1997
carol : 4/24/1998
psherman : 4/24/1998
mark : 12/14/1997
dholmes : 12/4/1997
alopez : 10/13/1997
alopez : 10/10/1997
alopez : 10/9/1997