MODIFIERS	DEFINITION	EXAMPLE
Biological Potential:
Carcinoma	Neoplasm originating from epithelium with proven malignant biological behavior.	Figures 2A,D,F
Adenocarcinoma	Neoplasm originating from glandular epithelium with proven malignant biological behavior.	Figures 2A,3A,3C
Adenoma	Neoplasm originating from glandular epithelium Without proven malignant biological behavior.	Figure 3H
Mammary Intraepithelial Neoplasia (MIN)	An intraluminal epithelial mass with cytologic atypia.	Figure 5
Hyperplasia	Any increase in cell number without cytologic atypia.
Tumor	Any space occupying mass with unknown biological potential.
Property:
Atypia	Cells with abnormal nuclear morphology.	Figure 5
Necrosis	Cell death generally not applied to programmed Cell death (apoptosis).	Figure 3I
Fibrosis	Increased or abnormal deposition of connective Tissue.	Figure 3F
Secretory	Tissues or glands producing and exporting lipid or protein	Figure 3G
Metaplasia	A change from one adult cell type to another adult Cell type.	Figures 3K and L
Topographic:
Diffuse	All of the mammary gland is involved in the process.
Focal	One area of the mammary gland is involved in the process.
Multifocal	Multiple foci are of the mammary gland have The lesion.
Inducer (Etiology):
Gene-induced	Tumors that have morphological or cytological Patterns characteristic of specific transgenes or Specific mutations. (myc-type, ras-type, erbB2-type)	Figure 4
MMTV-induced	Tumors known to be induced by the Mouse Mammary Tumor Virus (MMTV).	Figure 2
Chemically -induced	Tumors known to be induced by a chemical carcinogen.	Figure 2E, F
Hormone-induced	Tumors known to be induced by exogenous hormones
Biological/Experimental Context:
Biological	Parity, Pregnancy, Lactation, Involution, Hormones
Experimental	promotor, exogenous hormones or chemicals

NOTE: The images noted in these and other tables can be viewed at URL:

http://ccm.ucdavis.edu/tgmouse/jaxworkshop/anna/figures.html