TABLE 1:SUMMARY OF MODELS

TABLE 1:SUMMARY OF MODELS

Models
Transgene
Bitransgene/ exptal. manipulation
Species
Promoters References

Growth Factors FGF3 (INT2) WNT1 Mouse MMTV-LTR (Kwan et al., 1992; Muller et al., 1990)

FGF7 (KGF) Mouse MMTV-LTR (Kitsberg and Leder, 1996)

HEREGULIN(NDF) myc Mouse MMTV-LTR (Krane and Leder, 1996)

HGF Mouse MT (Takayama et al., 1997)

IGFII Mouse BGL, H19 (Bates et al., 1995; Pravtcheva and Wise, 1998)

TGF a p53-172H, myc, DMBA Mouse WAP, MMTV-LTR, MT (Coffey et al., 1994; Jhappan et al., 1990; Matsui et al., 1990; Sandgren et al., 1990; Sandgren et al., 1995)

TGF-b MMTV-infected Mouse WAP (Kordon et al., 1995)

Receptors TGFb DNIIR Mouse MMTV-LTR (Joseph et al., 1999)

ERB-B2 (neu) p53-172H Mouse, MMTV-LTR (Guy et al., 1992; Li et al., 1997; Muller et al., 1988)

RET Mouse MMTV-LTR (Iwamoto et al., 1990)

Tpr-MET Mouse MT (Liang et al., 1996)

Signal Pathways PyV-mT Mouse MMTV-LTR (Guy et al., 1992)

RAS Mouse MMTV-LTR (Sinn et al., 1987)

Cell Cycle CYCLIN D1 Mouse MMTV-LTR (Wang et al., 1994)

MYC BCL2 Mouse MMTV-LTR, WAP (Jager et al., 1997; Stewart et al., 1984)

p53-172H, p53 Mouse WAP, Null (Donehower et al., 1992; Li et al., 1997)

SV40TAg BCL-2 Mouse WAP, C(3)1 (Furth et al., 1999; Husler et al., 1998; Maroulakou et al., 1994; Tzeng et al., 1993)

Differentiation NOTCH4(INT3) TGF b Mouse MMTV-LTR, WAP (Gallahan et al., 1996; Smith et al., 1995)

WNT 1 Mouse MMTV-LTR (Tsukamoto et al., 1988)

WNT10b Mouse MMTV-LTR (Lane and Leder, 1997)

P-CADHERIN Mouse Null (Radice et al., 1997)

Other Transgenes Stromelysin Mouse WAP (Sternlicht et al., 1999)

MTS1 Mouse MMTV-LTR (Ambartsumian et al., 1996)

Transgenic Rat Models TGF a Rat MMTV-LTR (Davies et al., 1999)

SV40Tag Rat C(3)1 (Shibata et al., 1999)

ERB-B2 (neu) Rat MMTV-LTR (Davies et al., 1999)

Miscellaneous DMBA treated rat Rat (Russo et al., 1977)

MNU treated rat Rat (Anzano et al., 1994)

MMTV infected mouse Mouse (Rehm and Liebelt, 1996)

Transplants of DMBA

treated-p53^-/- mouse mammary epithelium
Mouse (Jerry et al., 1999)

Models	Transgene	Bitransgene/ exptal. manipulation	Species	Promoters	References

Growth Factors	FGF3 (INT2)	WNT1	Mouse	MMTV-LTR	(Kwan et al., 1992; Muller et al., 1990)
	FGF7 (KGF)		Mouse	MMTV-LTR	(Kitsberg and Leder, 1996)
	HEREGULIN(NDF)	myc	Mouse	MMTV-LTR	(Krane and Leder, 1996)
	HGF		Mouse	MT	(Takayama et al., 1997)
	IGFII		Mouse	BGL, H19	(Bates et al., 1995; Pravtcheva and Wise, 1998)
	TGF a	p53-172H, myc, DMBA	Mouse	WAP, MMTV-LTR, MT	(Coffey et al., 1994; Jhappan et al., 1990; Matsui et al., 1990; Sandgren et al., 1990; Sandgren et al., 1995)
	TGF-b	MMTV-infected	Mouse	WAP	(Kordon et al., 1995)

Receptors	TGFb DNIIR		Mouse	MMTV-LTR	(Joseph et al., 1999)
	ERB-B2 (neu)	p53-172H	Mouse,	MMTV-LTR	(Guy et al., 1992; Li et al., 1997; Muller et al., 1988)
	RET		Mouse	MMTV-LTR	(Iwamoto et al., 1990)
	Tpr-MET		Mouse	MT	(Liang et al., 1996)

Signal Pathways	PyV-mT		Mouse	MMTV-LTR	(Guy et al., 1992)
	RAS		Mouse	MMTV-LTR	(Sinn et al., 1987)

Cell Cycle	CYCLIN D1		Mouse	MMTV-LTR	(Wang et al., 1994)
	MYC	BCL2	Mouse	MMTV-LTR, WAP	(Jager et al., 1997; Stewart et al., 1984)
	p53-172H, p53		Mouse	WAP, Null	(Donehower et al., 1992; Li et al., 1997)
	SV40TAg	BCL-2	Mouse	WAP, C(3)1	(Furth et al., 1999; Husler et al., 1998; Maroulakou et al., 1994; Tzeng et al., 1993)

Differentiation	NOTCH4(INT3)	TGF b	Mouse	MMTV-LTR, WAP	(Gallahan et al., 1996; Smith et al., 1995)
	WNT 1		Mouse	MMTV-LTR	(Tsukamoto et al., 1988)
	WNT10b		Mouse	MMTV-LTR	(Lane and Leder, 1997)
	P-CADHERIN		Mouse	Null	(Radice et al., 1997)

Other Transgenes	Stromelysin		Mouse	WAP	(Sternlicht et al., 1999)
	MTS1		Mouse	MMTV-LTR	(Ambartsumian et al., 1996)

Transgenic Rat Models	TGF a		Rat	MMTV-LTR	(Davies et al., 1999)
	SV40Tag		Rat	C(3)1	(Shibata et al., 1999)
	ERB-B2 (neu)		Rat	MMTV-LTR	(Davies et al., 1999)

Miscellaneous	DMBA treated rat		Rat		(Russo et al., 1977)
	MNU treated rat		Rat		(Anzano et al., 1994)
	MMTV infected mouse		Mouse		(Rehm and Liebelt, 1996)
	Transplants of DMBA treated-p53^-/- mouse mammary epithelium		Mouse		(Jerry et al., 1999)