Figure 4

Figure 4:

Compares the typical phenotypes for neu (cerbB-2) (Figure 4A), myc (Figure 4B), ras (Figure 4C), and ret-1 (Figure D) The neu is described as a solid, nodular tumor type with slightly atypical nuclei that are intermediate in size between the large myc-type cells (Figure 4B) and the smaller ras-type cells (Figure 4C). The myc-type tumors have large pleomorphic nuclei with a course dark chromatin and dark, amphophilic cytoplasm. These tumors are very aggressive with invasive growth patterns. The ras tumors have small, uniform nuclei without significant pleomorphism with relatively abundant cytoplasm. The ras-type tumors tend to organize around blood vessels to form papillary type growths. The ret-1-type tumor forms distinctive glands which are lined by large cells with very pleomorphic nuclei and relatively little cytoplasm. (Space bar = 100 microns)

SLIDES: A: #192, NEU; B: #244, MYC; C: #198 , ras; D: #107, ret1

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FIGURE 1 (TDLU)

FIGURE 2 (non-GEM PATTERNS)

FIGURE 3 (GEM PATTERNS)

FIGURE 4 (SIGNATURE TUMORS)

FIGURE 5 (MIN GRADES)

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