Figure 4

Figure 4 provides comparisons between the typical phenotypes for erbB (neu ) (Figure 4A), myc (Figure 4B), ras (Figure 4C), and ret-1 (Figure D). The erbB-type tumor is a solid, nodular tumor type with slightly atypical nuclei that are intermediate in size between the large myc-type cells (Figure 4B) and the smaller ras-type cells (Figure 4C). The myc-type tumors have large pleomorphic nuclei with a course dark chromatin and dark, amphophilic cytoplasm. These tumors are very aggressive with invasive growth patterns. The ras-type tumors have small, uniform nuclei without significant pleomorphism with relatively abundant cytoplasm. The ras-type tumors tend to organize around blood vessels to form papillary type growths. The ret-1-type tumor forms distinctive glands that are lined by large cells with very pleomorphic nuclei and relatively little cytoplasm. The scale bar indicates 100 microns (Figure 4A).

SLIDES: A: #192, NEU; B: #244, MYC; C: #198 , ras; D: #107, ret1

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FIGURE 1 (TDLU)

FIGURE 2 (non-GEM PATTERNS)

FIGURE 3 (GEM PATTERNS)

FIGURE 4 (SIGNATURE TUMORS)

FIGURE 5 (MIN GRADES)

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