Figure 3
Figure 3 provides examples illustrating the various descriptors used in Tables 1 and 2 to characterize the patterns observed in GEM. Figure 2A is glandular with glands dilated by secretions. This image is from a WAP/TGF? tumor; B is acinar with small glandular structure with small lumens and minimal secretions. The image is from a MMTV-LTR/wnt10b tumor; C is cribriform with back-to-back glands. The image is from a Bcl/myc tumor; D is papillary well differentiated with finger-like projects of fibrovascular stroma covered with neoplastic epithelium. This image is from a MTV-LTR:TGFa mouse; E is solid with sheets of tumor cells with little or no intervening stroma. This image is from a MMTV/DNIIR tumor; F is sclerotic with a dense connective tissue stroma separating strands of invasive tumor cells. This image is from a MMTV-LTR/int-3 tumor; G shows invasion between muscle fibers in a bigenic WAP/TGFa x WAP/myc tumor; H shows an expansile non-invasive pattern at the edge of an adenoma and lactating mammary gland in a bigenic WAP/p53-172 x WAP/TGFa mouse; I has necrosis at the center of a dilated glandular structure. This image is from a BLG/igf-2 tumor; J is a carcinosarcoma tumor with sarcomatous and carcinomatous components from a WAP/stromelysin-1 mouse, K is a mammary tumor with cartillagenous and osseous metaplasia from a WAP/stromelysin-1 mouse; L is a adenosquamous carcinoma from a MMTV/heregulin mouse. The scale bar indicates 100 microns (Figure 3A).