24. Muller, W.J., C..L. Arteaga, S.K. Muthuswamy, P.M. Siegel, M.A. Webster, R.D. Cardiff, K.S. Meise, F. Li, S.A. Halter and R. Coffey. Synergistic interaction of the Neu protooncogene and TGFa in the mammary epithelium of transgenic mice. Molecular and Cellular Biology. 16:5726-5736, 1996. (ABSTRACT)(ILLUSTRATIONS)


LEGEND:
Whole-mount analyses of mammary fat pads derived from monogenic and bigenic female mice. Shown are whole-mount preparations illustrating the appearance of mammary trees from a lactating FVB female (A), A virgin female with the neu transgene (note the numerous side buds which give the mammary tree a spiculated appearance) (B), a virgin female with the TGF-a transgene (note the well developed, cystically dilated alveoli) (C), and a virgin female with both the TGF-a and neu transgenes (note the larger alveoli with darker walls, indicating a denser cell lining in the walls) (D), Compare these preparations with the comparable histological preparations in Figure 2. Original magnification X31.5

LEGEND:
Histopathology of mammary tissues derived from virgin monogenic and bigenic transgenic animals. (A) Normal FVB lactating female mouse showing lobulo-alveolar development ad milk productions. (B) Transgenic neu virgin female mouse illustrating rudimentary mammary acinar development without significant luminal secretions.(C) Transgenic TGF-a virgin female mouse illustrating extensive alveolar development in comparison with a lactating mammary gland (A). Note that the alveoli are much more distended with secretory products that the FVB lactating tissue but contain fewer clear lipid vacuoles. (D) Transgenic neu/TGF-a virgin female mouse illustrating areas of alveolar development with papillary hyperplasia in the upper right corner. The virgin neu, TGF-a and neu/TGF-a mice were age matched (139 days) and identical to those described in Fig 1.

Other Example Images:
MT TUMORS
Db TUMORS
250 TUMORS
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Last Updated: November 27, 1996