18. Webster, MA; Cardiff, RD; Muller, WJ. Induction of mammary epithelial hyperplasias and mammary tumors in transgenic mice expressing a murine mammary tumor virus/activated c-src fusion gene. Proceedings of the National Academy of Sciences of the United States of America, 1995 Aug 15, 92(17):7849-53. (ABSTRACT)(ILLUSTRATIONS)(UI: 95372376) ;

LEGEND:
Photomicrographs of hematoxylin and eosin-stained 7-:m-thick paraffin sections (A) A hyperplastic alveolar focus from a mammary gland of a c-src 527F female with inflammation in the center of the field. Compare this focus with the portions of normal mammary duct in the upper right corner in the midst of the fat. (B) A scirrhous adenocarcinoma from a mammary gland of a c-src 527F female invading skeletal muscle. (C) A section of mammary gland from a normal, nontransgenic FVB female mouse 1 day after delivery of a litter. Note crowded alveoli with the large number of clear lipid vacuoles in the cytoplasm and in the lumen of the acini. (D) A section of mammary gland from a c-src 527F female one day after delivery of a litter. Note the relative lack of luminal contents, the lack of clear lipid vacuoles, and the mature residual fat.

LEGEND:
Slide-mounted, whole-mount preparations of hematoxylin-stained mammary glands comparing the subgross morphology of nontransgenic FVB (A and C) with transgenic c-src 527F (B and D) females 15 days after conception (A and B) and 1 day after delivery of the litter (C and D). Note that the midpregnant transgenic c-src 527F mammary gland (B) has fewer developing lobules than the normal FVB (A). The few developing lobules stand out from the background as hyperplastic foci. The lactating mammary gland of the FVB (C) fills the fat pad, while the transgenic c-src 527F mammary gland (D) has very few fully developmed lobules.
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Last Updated: November 06, 1996