6. Guy, CT; Cardiff, RD; Muller, WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Molecular and Cellular Biology, 1992 Mar, 12(3):954-61. (ABSTRACT)(ILLUSTRATIONS)(UI: 92186880);

LEGEND:
Figure 3 Histopathology of MMTV/middle T transgenic mice. (A) Photomicrograph of a hematoxylin-stained whole mount of the mammary fat pad of a wild-type virgin mouse at 3 weeks of age showing normal growth and development. Magnification, x16. (B) Photomicrograph of a hematoxylin-stained whole mount of the mammary fat pad of an MT#634 virgin transgenic female (MT 907) at 21 days of age. Compare with panel A. Note the irregular formation of side branches, enlarged terminal buds, and two large multilobular tumor masses (arrows). Magnification, x16. (C) Photomicrograph of a sclerosing mammary adenocarcinoma from a middle T transgenic multiparous female mouse (MT#634 15 110 days). Note the dense connective tissue separating the attenuated cords of poorly differentiated mammary tumor cells. This pattern is typical of these transgenic mice. Magnification, x87. (D) Photomicrograph of the lungs of the same mouse showing multiple metastases. Note that the tumor cells form well-defined acinar structure, with very little stroma separating the epithelium. Also note that the tumor cells are intra-alveolar rather than intravascular, indicating growth outside of the vessels, Magnification, x87.

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