• Histology and computer-assisted intravital microscopy demonstrated that internal microcirculation in Met-1 was more complex than Db-7; Met-1 exhibited higher microvessel density and tortuosity (P<0.0001) .
• These indices of microvascular complexity correlated with the higher Met-1 metastatic rate (P<0.0001).
• These transplantable lines will be useful for investigating the complex relationship between angiogenesis and metastasis.
• THIS HAS TURNED OUT TO BE A GREAT MODEL FOR THE STUDY OF ANGIOGENESIS.