• THE NORMAL MICROCIRCULATION CONSISTS OF STRAIGHT VESSELS (CONTROL).
• FOUR DAYS AFTER TRANSPLANTATION OF A MET-1 TUMOR (HIGHLY METASTATIC), NEOANGIOGENIC VESSELS CAN BE OBSERVED.
• BY 10 AND 13 DAYS THE VESSELS ARE SHOW INCREASING COMPLEXITY WITH INCREASING TORTUOSITY AND AV SHUNTS.
• BY 23 DAYS, THE INTERNAL VESSELS ARE COMPLEX ARRAYS OF DILATED WORM-LIKE CHANNELS.
• THE EXTERNAL (SURFACE) VESSELS ARE ALSO COMPLEX BUT RUN STRAIGHTER COURSES.
• THE DIFFERENCES IN MICROCIRCULATION COULD BE QUANTITATED USING SEVERAL METHODS. (NEXT SLIDE)