• PULMONARY METASTASES COULD BE DETECTED BY GROSS AND MICROSCOPIC EXAMINATION OF THE LUNGS IN ANIMALS WITH TRANSPLANT TUMORS.
• OTHER ORGANS DID NOT HAVE METASTASES.
• HOWEVER, THERE IS A MARKED DIFFERENCE IN THE RATE OF METASTASES BETWEEN THE WILD TYPE AND THE DOUBLE BASE MUTANT TUMORS (NEXT SLIDE).