Plate 6 illustrates the histology of typical MMTV-induced "spontaneous" mouse mammary tumors (Figures 6A and 6B) as described by Dr. Thelma Dunn with human breast cancers (Figures 6C, 6F and 6G) and comparable mouse mammary tumors induced by transgenes (Figures 6D, 6F and 6H).

A. Microscopic image of a mouse Dunn Type A tumor (~400x).
B. Microscopic image of a mouse Dunn Type B tumor (~400x).
C. Microscopic image of a human DCIS showing the solid pattern (see Figures 4A to 4C) (~100X).
D. Microscopic image of a tumor from a mouse with the neu transgene showing the terminal ducts filled with cells with some central necrosis (comedo pattern) (see Figure 4C) (~100X).
E. Microscopic image of a human scirrhous carcinoma. Note the narrow cords of tumor cells in a dense connective tissue. The evolution of this type of tumor is illustrated in Figure 4) (~400x).
F. Microscopic image of a mouse scirrhous carcinoma in a mouse with the src transgene. Compare this pattern with the human scirrhous carcinoma (Figure 6E) (~400x).
G. Microscopic image of a human papillary carcinoma. Note that the neoplastic epithelium covers a fibrovascular stalk (~75x).
H. Microscopic image of a papillary tumor from a mouse with the casein kinase II transgene. Compare the pattern with the human papillary carcinoma Figure 6G) (~70x).