Plate 2 illustrates the digital images of the human (Figures 2A, 2C, 2E and 2G) as compared with the mouse (Figures 2B, 2D, 2F and 2H) mammary glands. The fully developed human TDLU (Figures 2A and 2C) and ALA (Figures 2E and 2G) are compared to the mouse LA (Figures 2B and 2D) and HAN (Figures 2F and 2H).

A. Subgross image of a human mammary duct with multiple TDLUs (~10x).

B. Subgross image of a mouse mammary duct with multiple LA units. This animal has been stimulated with KGF prior to sacrifice (Courtesy of Ruth Lang) (~15x)

C. Subgross image of human TDLUs, emphasizing the grape-like appearance (~.25x)

D. Subgross mouse LA units attached to a dilated duct This animal has been stimulated with KGF prior to sacrifice(Courtesy of Ruth Lang) (~15x)

E. Subgross a human ALA (~25x). Note the very dense staining pattern due to the tightly packed cells (See Figure 3).

F. Subgross several mouse HANs. This animal was infected with the Mouse Mammary Tumor Virus. (~100x).

G. Microscopic appearance of a human low grade ALA. Note the irregular pattern of the acini in comparison to the normal TDLU (Figure 1C) and the multiple layers of cells. (~100x).

H. Microscopic image of a mouse HAN. Note the densely crowded acinar structures without atypia. The stroma is inflamed (~100x).