TRANSGENIC ONCOGENE MICE: GENOTYPE PREDICTS TUMOR PHENOTYPE
ABSTRACT
The hypothesis that oncogenes influence tumor phenotype was tested by examining slides from 607 mammary tumors from 407 transgenic mice bearing the ras, myc, and/or neu oncogenes. Most tumors (91%) had patterns (phenotypes) which could not be classified by Dunn's standard nomenclature. The non-standard tumors were described as eosinophilic small cell (SC), basophilic large cell (LC) or pale intermediate cell (IC). The SC tumor was associated with ras, the LC with myc and IC with neu with specificities over .90 and sensitivities ranging from .99 to .48. Thus, the tumor phenotype could be used to predict which oncogene was present in the animal. The presence of myc in combination with either ras or neu resulted in the predominance of LC tumors and accelerated tumorigenesis. The combination of ras and neu resulted in a decreased tumor incidence. Thus, knowledge of the oncogenes present could be used to predict the natural history of the disease.
(Cardiff,R.D., E. Sinn, W. Muller, and P. Leder.
Transgenic Oncogene Mice: Tumor phenotype predicts genotype.
Am. J. Path. 139(3):495-501, 1991.)
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For 1990-1995 Data Base: See our classification of mammary tumors from animals with one or two Transgenes
(Munn R.J., M. Webster, W.J. Muller and R.D. Cardiff. Histopathology of transgenic mouse mammary tumorigenesis (A Short Atlas). Seminars in Cancer Biology 6:153-158, 1995)