Current Transgenic Mouse Images

Recent IHC for NEU

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IP with Anti- NEU

Samples from the laboratory of Dr. William J. Muller, Mc Master University, Hamilton, Ontario, Canada.



LEGENDS


Figure 1. Photomicrograph illustrating the distribution of anti-neu staining in the terminal end bud of a 7 week old female FVB mouse. Note that the stain is along the luminal margin. (220x)
Figure 2. Photomicrograph illustrating the distribution of anti-neu staining in a lactating mammary gland of a multiparous TGFaxneu female. Note the dense island of stain surrounded by non-staining mammary tissues. ( 60x)
Figure 3. Photomicrograph illustrating the distribution of anti-neu staining in the alveoli of a lactating neu mouse. Note that the stain is along the basolateral margins and that adjacent mammary gland does not stain. The non-staining alveolar cells have smaller nuclei and cells. (220x)
Figure 4. Photomicrograph illustrating the distribution of anti-neu staining in an area of atypical hyperplasia in a female TGFaxneu mouse. While the whole mammary gland is hyperplastic the neu positive tissue has smaller lumina and larger cells. (220x)
Figure 5. Photomicrograph illustrating the distribution of anti-neu staining in the tumor of a animal with the neu transgene. Note that the stain is along the cell membrane creating a honeycomb pattern. ( 220 x)


color black and white color black and white
A) TG93-0335 B) TG93-0335 C) TG94-0405 D) TG94-0405
FVB NORMAL FVB NORMAL NEU DYSPLASIA NEU DYSPLASIA
E) TG94-418 F) TG94-418 G) TG94-419 H) TG94-419
NEU TUMOR NEU TUMOR NEU HYPERPLASIA NEU HYPERPLASIA
I) TG94-419 J) TG94-419 K) TG95-0186 L) TG95-0186
           
NEU HYPERPLASIA NEU HYPERPLASIA NEU LACTATION NEU LACTATION
M) TG95-0186 N) TG95-0186 O) TG95-0186 P) TG95-0186
NEU LACTATION NEU LACTATION NEU LACTATION NEU LACTATION
Q) TG95-0186 R) TG95-0186 S) TG95-0186 T) TG95-0186
NEU LACTATION NEU LACTATION NEU LACTATION NEU LACTATION

CONTROL TUMOR
TG94-418

 



What do you think?


Dr. Robert D. Cardiff, M.D.,Ph.D.

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LAST ENTERED JULY 17, 1996