ANATOMY OF THE AGING LOBULE

As the woman ages, the lobule also undergoes characteristic atrophy. This set of images show the typical changes.

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Slide 36. This "Normal" lobule is from a non-pregnant 49 year old female with breast cancer. It has the appearance of a younger female. However, women with breast cancer retain a youthful breast parenchyma. Photographed at 63x magnification.
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Slide 37. This normal lobule is from a 43 year old female with no breast cancer. Note the thickened basement membranes around the ductules. The lobule is starting to become sclerotic. Photographed at 63x magnification.
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Slide 38. This normal lobule displays fewer ductules and denser intralobular stroma. Non-cancerous breast from an 83 year old female. Photographed at 63x magnification.

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Slide 39. In this breast slice the lobules show moderate atrophy. An arrow points to the TD draining one. Note the distended duct tree (D). From a 59 year old female with no breast cancer. Photographed at 8x magnification.
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Slide 40. This breast slice shows complete atrophy of TDLU but the branching duct tree will remain forever. From a 52 year old female with no breast cancer. Photographed at 1x magnification.
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Slide 41. This breast slice shows the branching duct tree distended with secretion and a few remnants of lobules. The flowering tree of the young breast has become cacti in the desert. Photographed at 4x magnification.

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Slide 42. This breast slice illustrates the branching duct tree and a single well developed TDLU with a delicate TD. The microarchitecture of TDLU is recapitulated in pre-cancerous lesions and ductule carcinoma in-situ, as you will see later. Photographed at 2.5x magnification.
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Slide 43. In this slice the punctate appearance of the lobule is due to the individual ductules making it possible to discern it as a normal lobule. Photographed at 10x magnification.
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Slide 44. This fresh slice of breast has been stained supravitally with methylene blue chloride. The lobules have the same punctate appearance so the structures are normal lobules. Photographed at 6x magnification.

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Slide 45. Two such supravitally stained lobules have been dissected for experiments. They are alive. Photographed at 6x magnification.

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slide36.jpg 766.85 Kb Slide 36. This "Normal" lobule is from a non-pregnant 49 year old female with breast cancer. It has the appearance of a younger female. However, women with breast cancer retain a youthful breast parenchyma. Photographed at 63x magnification.	slide37.jpg 688.89 Kb Slide 37. This normal lobule is from a 43 year old female with no breast cancer. Note the thickened basement membranes around the ductules. The lobule is starting to become sclerotic. Photographed at 63x magnification.	slide38.jpg 734.33 Kb Slide 38. This normal lobule displays fewer ductules and denser intralobular stroma. Non-cancerous breast from an 83 year old female. Photographed at 63x magnification.
slide39.jpg 404.50 Kb Slide 39. In this breast slice the lobules show moderate atrophy. An arrow points to the TD draining one. Note the distended duct tree (D). From a 59 year old female with no breast cancer. Photographed at 8x magnification.	slide40.jpg 463.21 Kb Slide 40. This breast slice shows complete atrophy of TDLU but the branching duct tree will remain forever. From a 52 year old female with no breast cancer. Photographed at 1x magnification.	slide41.jpg 432.95 Kb Slide 41. This breast slice shows the branching duct tree distended with secretion and a few remnants of lobules. The flowering tree of the young breast has become cacti in the desert. Photographed at 4x magnification.
slide42.jpg 510.35 Kb Slide 42. This breast slice illustrates the branching duct tree and a single well developed TDLU with a delicate TD. The microarchitecture of TDLU is recapitulated in pre-cancerous lesions and ductule carcinoma in-situ, as you will see later. Photographed at 2.5x magnification.	slide43.jpg 544.76 Kb Slide 43. In this slice the punctate appearance of the lobule is due to the individual ductules making it possible to discern it as a normal lobule. Photographed at 10x magnification.	slide44.jpg 458.29 Kb Slide 44. This fresh slice of breast has been stained supravitally with methylene blue chloride. The lobules have the same punctate appearance so the structures are normal lobules. Photographed at 6x magnification.
slide45.jpg 303.87 Kb Slide 45. Two such supravitally stained lobules have been dissected for experiments. They are alive. Photographed at 6x magnification.