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Slide 178. Flow cytometry is used to measure DNA content. This is a diploid
cell population. |
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Slide 179. This breast cancer is aneuploid . |
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Slide 181. This invasive cribriform carcinoma is positive for ESTROGEN RECEPTORS
(ER) by immunohistochemistry. Photographed at 25x magnification |
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Slide 182. This ER positive invasive breast cancer is moderately well differentiated.
Photographed at 63x magnification |
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Slide 183. The ER positive cancer cells are readily seen in this lymphnode.
Photographed at 25x magnification |
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Slid 184. The brown nuclei are in the secretory DNA phase when stained with
Ki-67. Few cells are undergoing replication in this moderately well
differentiated cancer. Photographed at 63x magnification |
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Slide 185. This poorly differentiated breast cancer has many Ki-67-positive
cells. Note the positive staining of mitotic figures as well. Photographed
at 63x magnification |
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Slide 186. Few mutations of P53 suppressor protein are noted in this moderately
well differentiated breast cancer. Photographed at 63x magnification |
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Slide 187. This poorly differentiated breast cancer is very positive for
P53 mutation. Photographed at 63x magnification |
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Slide 188. HER 2 / NEU positivity at the cytoplasmic membranes in
this moderately well differentiated breast cancer may signify higher change
of recurrence of the cancer after primary therapy. Photographed at 63x magnification |
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Slide 189. CD34 a marker for endothelial cells outlines two lymphatic vessels
filled with cancer cells. (Arrows) Photographed at 63x magnification |
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This chart summarizes Dr. Jensen's ideas about the morphogenesis of human
breast cancer. |
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