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Slide 106. The histologic pattern of cribriform DCIS with extensive necrosis (N) in the unfolding lobules. The arrow points to the area magnified. Photographed at 10x magnification
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Slide 107. The necrosis makes it so-called COMEDO CARCINOMA. Grossly the examining hand can squeeze the necrotic debris out like comedones in the skin. Photographed at 63x magnification
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Slide 108. A large field of DCIS is seen with dark, calcified, necrotic debris. Such minute irregular calcifications on a mammogram are highly suspicious radiologically for this kind of DCIS. Photographed at 6.3x magnification
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Slide 109. At higher magnification the arrow points to a possible focus of lymphatic spread. Photographed at 25x magnification
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Slide 110. This focus of cribriform DCIS contains minute foci of necrotic calcified debris. Photographed at 25x magnification