INVASIVE BREAST CANCER

This page provides the gross, subgross and microscopic view of invasive breast cancer in humans. The page emphasizes the "NOS" type of cancer with the Elston grading system.

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Slide 150. Gross specimen of invasive breast cancer. The arrow points to the infiltrating edge.
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Slide 151. The infiltrative breast cancer is seen in this slice with the naked eye.
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Slide 152. The infiltrative pattern is seen in this subgross. Photographed at 6.3x magnification
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Slide 153. The ELSTON GRADING SYSTEM is used to estimate the aggressiveness of invasive ductal carcinoma of the "garden variety" or not otherwise specified (NOS) that constitutes ~85% of all breast cancers.

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Slide 154. Several foci of in-situ ductal carcinoma are seen. The arrow points to a focus of invasion. This is in-situ ductal carcinoma with MICROINVASION. Photographed at 25x magnification
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Slide 155. Many foci of in-situ ductal carcinoma are seen with central necrosis (N). The tumor has invaded extensively as seen in the lower left area. Invasive ductal carcinoma is called that because of its association with ductal in-situ carcinoma. Photographed at 10x magnification
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Slide 156. The invasive ductal carcinoma forms many tubules (Grade 1). Nuclei show moderate variation in size or shape (Grade 2). Few mitoses are seen (Grade 1). This is a well differentiated breast cancer. Photographed at 63x magnification
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Slide 157. This invasive ductule carcinoma shows no tubules (Grade 3). Nuclei show moderate variation in size and shape (Grade 2). Few mitoses are noted (Grade 1). A moderately well differentiated breast cancer. Photographed at 63x magnification

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Slide 158. Large foci of invasive breast cancer with no tubules (Grade 3). Nuclei show moderate variation in size and shape (Grade 2). No mitotic figures are noted (Grade 1). This is another moderately differentiated invasive ductal carcinoma. ~80% of the garden variety fall into this level of differentiation. Photographed at 63x magnification
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Slide 159. This invasive ductal carcinoma forms no tubules (Grade 3). Nuclei are displaying marked variation in size and shape (Grade 3). Arrows point to mitoses that are seen at a rate of 10-19/ten high power fields (Grade 2). This is a poorly differentiated breast cancer.
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Slide 160. Another example of a poorly differentiated invasive ductal carcinoma. The arrow points to a multinucleated tumor giant cell. Measure the nuclei size by comparison to the lymphocytes in the lower left corner. Photographed at 63x magnification

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slide150.jpg 546.37 Kb Slide 150. Gross specimen of invasive breast cancer. The arrow points to the infiltrating edge.	slide151.jpg 369.54 Kb Slide 151. The infiltrative breast cancer is seen in this slice with the naked eye.	slide152.jpg 391.53 Kb Slide 152. The infiltrative pattern is seen in this subgross. Photographed at 6.3x magnification	slide153.jpg 525.58 Kb Slide 153. The ELSTON GRADING SYSTEM is used to estimate the aggressiveness of invasive ductal carcinoma of the "garden variety" or not otherwise specified (NOS) that constitutes ~85% of all breast cancers.
slide154.jpg 957.61 Kb Slide 154. Several foci of in-situ ductal carcinoma are seen. The arrow points to a focus of invasion. This is in-situ ductal carcinoma with MICROINVASION. Photographed at 25x magnification	slide155.jpg 1030.96 Kb Slide 155. Many foci of in-situ ductal carcinoma are seen with central necrosis (N). The tumor has invaded extensively as seen in the lower left area. Invasive ductal carcinoma is called that because of its association with ductal in-situ carcinoma. Photographed at 10x magnification	slide156.jpg 567.61 Kb Slide 156. The invasive ductal carcinoma forms many tubules (Grade 1). Nuclei show moderate variation in size or shape (Grade 2). Few mitoses are seen (Grade 1). This is a well differentiated breast cancer. Photographed at 63x magnification	slide157.jpg 700.83 Kb Slide 157. This invasive ductule carcinoma shows no tubules (Grade 3). Nuclei show moderate variation in size and shape (Grade 2). Few mitoses are noted (Grade 1). A moderately well differentiated breast cancer. Photographed at 63x magnification
slide158.jpg 731.16 Kb Slide 158. Large foci of invasive breast cancer with no tubules (Grade 3). Nuclei show moderate variation in size and shape (Grade 2). No mitotic figures are noted (Grade 1). This is another moderately differentiated invasive ductal carcinoma. ~80% of the garden variety fall into this level of differentiation. Photographed at 63x magnification	slide159.jpg 913.35 Kb Slide 159. This invasive ductal carcinoma forms no tubules (Grade 3). Nuclei are displaying marked variation in size and shape (Grade 3). Arrows point to mitoses that are seen at a rate of 10-19/ten high power fields (Grade 2). This is a poorly differentiated breast cancer.	slide160.jpg 812.96 Kb Slide 160. Another example of a poorly differentiated invasive ductal carcinoma. The arrow points to a multinucleated tumor giant cell. Measure the nuclei size by comparison to the lymphocytes in the lower left corner. Photographed at 63x magnification