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Deckard-Jantapour, K., W.J. Muller, L. Chodosh, H.P. Gardner, S.T. Marquis, R.J. Coffey and R.D. Cardiff. Differential expression of the neu transgene in murine mammary tissues. Int. J. Oncology 1997,11:235-244. (ABSTRACT)(ILLUSTRATIONS)

Figure 1. Photomicrograph illustrating the distribution of anti-neu staining in the terminal end bud of a 7 week old female FVB mouse. Note that the stain is along the luminal margin. (220x) Figure 2. Photomicrograph illustrating the distribution of anti-neu staining in a lactating mammary gland of a multiparous TGFaxneu female. Note the dense island of stain surrounded by non-staining mammary tissues. ( 60x) Figure 3. Photomicrograph illustrating the distribution of anti-neu staining in the alveoli of a lactating neu mouse. Note that the stain is along the basolateral margins and that adjacent mammary gland does not stain. The non-staining alveolar cells have smaller nuclei and cells. (220x) Figure 4. Photomicrograph illustrating the distribution of anti-neu staining in an area of atypical hyperplasia in a female TGFaxneu mouse. While the whole mammary gland is hyperplastic the neu positive tissue has smaller lumina and larger cells. (220x) Figure 5. Photomicrograph illustrating the distribution of anti-neu staining in the tumor of a animal with the neu transgene. Note that the stain is along the cell membrane creating a honeycomb pattern. ( 220 x)

Figure 6
A. Photomicrograph illustrating the H&E staining in an area of atypical hyperplasia in a female TGFaxneu mouse. While the whole mammary gland is hyperplastic, the neu positive tissue has smaller lumina and larger cells(see B and C) (125x)
B. Photomicrograph illustrating the distribution of anti-neu staining in an area of atypical hyperplasia in a female TGFaxneu mouse. While the whole mammary gland is hyperplastic the neu positive tissue has smaller lumina and larger cells. (125x)
C. A photomicrograph showing a darkfield image of in-situ hybridization of a similar area in the same tissue block. Note that the greatest grain intensity is over the neu positive cells. (125x)

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