23. Tulchin, N., F.S. Lee, L. Ornstein, J. Strauchen and R.D. Cardiff. Immunohistologic c-
myc protein in benign breast disease and cancer. Int. J. Oncology 9:419-425, 1996.
(ABSTRACT)(ILLUSTRATIONS)
LEGEND:[The left hand image is the H&E stained slide and the right hand image is the IHC stain for myc. Note that the myc antigen is nuclear.]Figure 1. a.TG.S 1580 H&E stained non-neoplastic portion of the mammary fat pad of specimen "A" b. Immunoperoxidase staining of a similar region, note the slight but variable staining of the nuclei with anti-Myc in the mammary ducts. Also note that the adjacent fat cells do not stain. c. Subsequent section of H&E stained dysplastic mammary gland with dilated ducts containing inspissated acellular eosinophilic debris d.Immunoperoxidase stain for Myc of a section adjacent to c, showing Myc specific staining in the nuclei of the ductal and alveolar cells e. FVB control mouse tissue, immunoperoxidase stain for Myc is negative.
LEGEND:[The left hand image is the H&E stained slide and the right hand image is the IHC stain for myc. Note that the myc antigen is nuclear.]. a. TG.M 1744/45. H&E stained section from a type A mammary tumor of Dunn composed of small solid nests of tumor cells surrounded by narrow bands of fibrovascular stroma, specimen "N" b. The immunoperoxidase stain of the same tumor showing that the epithelial cells are positive for nuclear Myc antigen; strikingly, the most intense nuclear stain tends to be at the periphery of the tumor nests, creating a peripheral palisade
LEGEND:[The left hand image is the H&E stained slide and the right hand image is the IHC stain for myc. Note that the myc antigen is nuclear. This photomicrograph shows the most dramatic staining.] Human breast tissue a. H&E section showing intraductal and infiltrating duct carcinoma b. The immunoperoxidase stain of the same tumor showing the intense, focally heterogeneous, Myc staining of the epithelial cell nuclei c. H&E section showing infiltrating duct carcinoma d. Immunoperoxidase stain of the same tumor showing strong Myc staining of greater than 90% of the tumor cell nuclei
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Last Updated: November 14, 1996
LEGEND:[The left hand image is the H&E stained slide and the right hand image is the IHC stain for myc. Note that the myc antigen is nuclear.]. a. TG.M 1744/45. H&E stained section from a type A mammary tumor of Dunn composed of small solid nests of tumor cells surrounded by narrow bands of fibrovascular stroma, specimen "N" b. The immunoperoxidase stain of the same tumor showing that the epithelial cells are positive for nuclear Myc antigen; strikingly, the most intense nuclear stain tends to be at the periphery of the tumor nests, creating a peripheral palisade 
LEGEND:[The left hand image is the H&E stained slide and the right hand image is the IHC stain for myc. Note that the myc antigen is nuclear. This photomicrograph shows the most dramatic staining.] Human breast tissue a. H&E section showing intraductal and infiltrating duct carcinoma b. The immunoperoxidase stain of the same tumor showing the intense, focally heterogeneous, Myc staining of the epithelial cell nuclei c. H&E section showing infiltrating duct carcinoma d. Immunoperoxidase stain of the same tumor showing strong Myc staining of greater than 90% of the tumor cell nuclei
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