19. Guy, CT; Cardiff, RD; Muller, WJ. Activated neu induces rapid tumor progression. Journal of Biological Chemistry, 1996 Mar 29, 271(13):7673-8. (ABSTRACT)(ILLUSTRATIONS)(UI: 96205956) ;

LEGEND:
Photomicrographs of hematoxylin and eosin stained slides. The organization and distribution of mammary cells are compared in the following: the mammary fat pad of a nontransgenic FVB mouse control demonstrating well spaced ducts lined by a single layer of epithelial cells (87x)(A); the mammary fat pad of an activated neu transgenic animal demonstrating a dilated collecting duct with adjacent areas of dysplastic cystic alveoli and solid neoplastic alveolar development (NT163, 173 days of age) (87x) (B); the solid neoplastic area of the gland in panel B enlarged to demonstrate dysplastic cells filling the mammary lobules but without growth through the basement membrane, thereby fulfilling the criteria of carcinoma in situ (350x) (C); and a typical malignant nodular tumor showing the nuclear pleomorphism and irregular, invasive growth pattern of a mammary adenocarcinoma found in animals with the activated neu transgene (NT163, 173 days of age)(350X)(D).


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Last Updated: November 06, 1996