17. Cardiff, R.D. Understanding transgenes in mammary tumorigenesis: Five Rules. J. Mammary Gland Biology and Neoplasia. 1995 1:61-73.
(ABSTRACT)(ILLUSTRATIONS)
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Figure 2 The morphology of typical tumor phenotypes. Photomicrographs illustrating four of the tumor phenotypes at high magnification (all 500x; reduced 6% for reproduction)to emphasize the differences in cytologic details as well as the growth pattern. (A) A typical field in a neu-induced tumor. Note the peripheral palisade of the cells. The nuclei have a delicate chromatin and are intermediate in size. The cytoplasm stains a light pink. (B) A typical field in a ras-induced tumor. Note that the nuclei are oriented toward the central vessel and are small and compact with a delicate chromatin. The cytoplasm stains a bright pink. (C) A typical field in a myc-induced tumor. The tumors tend to have ill-formed glands lined by cells with large, pleomorphic nuclei containing coarsely clumped chromatin. The cytoplasm stains dark and amphophilic. (D) A typical field in a Py V-MT-induced adenocarcinoma. These tumors have abundant stroma.
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Last Updated: November 06, 1996
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MT TUMORS