16. Munn, RJ; Webster, M; Muller, WJ; Cardiff, RD. Histopathology of transgenic mouse
mammary tumors (a short atlas).
Seminars in Cancer Biology, 1995 Jun, 6(3):153-8. (ABSTRACT)(ILLUSTRATIONS)(UI: 96121868);
LEGEND:The histology of normal mammary development. (A) Fully developed mammary gland from virgin FVB female (Omnifix). (B) Hormone-stimulated mammary gland from seven day pregnant FVB female (Ominfix). (C) Lactating mammary gland from FVB female (Omnifix). (D) Regressing post-weaning mammary gland from FVB female (Omnifix).
(E) Hyperplastic alveolar nodule from GR female (Tellyesnicky's fixative) (D. Morris) (Han). (F) Hormone-dependent tumor or plaque from GR female (Tellyesnicky's fixative) (D. Morris) .
LEGEND:The subgross (whole mount) morphology of mammary hyperplasia. (A) Regressing mammary tree with focal MuMTV-induced hyperplastic alveolar nodule (HAN) from GR female (D. Morris). (B) Hyperplastic mammary tree from int-2 transgenic FVB mouse (D. Ornitz). (C) Lactating mammary gland from non-transgenic FVB female (M. Webster/Wm. Muller). (D) Hyperplastic mammary tree from virgin TGF transgenic FVB mouse (M. Webster/Wm. Muller). (E) Hyerplastic mammary tree from virgin Polyoma Virus middle T transgenic FVB mouse. Note multiple focal dysplasia (Wm. Muller). (F) Hyperplastic mammary tree from src 527 transgenic FVB mouse. Note focal dysplasia (M. Webster/Wm. Muller).
LEGEND:The histopathology of mammary tumors (A) MuMTV-induced Dunn Type A mammary tumor with acinar pattern in GR mouse (Tellyesnicky's fixative) (D. Morris). (B) MuMTV-induced Dunn Type B mammary tumor with mixed cord-like and cystic patterns in GR mouse (Tellyesnicky's fixative ) (D. Morris). (C) Nodular carcinoma, intermediate cell type, from FVB mouse with neu transgene (Wm. Muller)(formalin fix). (D) Papillary transitional carcinoma, small cell type, from FVB mouse with ras transgene (Omnifix) (P. Leder). (E) Papillary carcinoma with sclerosis from FVB mouse with PyV-middle T transgene (formalin fix) (Wm. Muller). (F) Papillary carcinoma from mouse with FVB int-2 transgene (Omnifix)(P.Leder). (E) Papillary carcinoma with sclerosis from FVB mouse with PyV-middle T transgene (formalin fix) (Wm. Muller). (F) Papillary carcinoma from mouse with FVB int-2 transgene (Omnifix) (P.Leder/F.Lee).
LEGEND:The histopathology of mammary adenocarcinomas. (A) Adenosquamous carcinoma from FVB mouse with cyclin-D1 transgene (formalin fix) (E. Schmidt). (B) Adenocarcinoma, large cell type, from FVB mouse with myc transgene (Omnifix)(P.Leder). (C) Adenocarcinoma, tubular, from FVB mouse with TGF transgene (formalin fix) (M.Webster). (D) Adenocarcinoma, small acinar type, from mouse with int-1 transgene (formalin fix) (R.C. Guzmann). (E) Scirrhous carcinoma from FVB mouse with src transgene (formalin fix) (M. Webster).(F) High magnification of the ras (r), neu (n), and myc (m) tumors showing differences in nuclear detail (Omnifix)(Leder).
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LEGEND:The histology of normal mammary development. (A) Fully developed mammary gland from virgin FVB female (Omnifix). (B) Hormone-stimulated mammary gland from seven day pregnant FVB female (Ominfix). (C) Lactating mammary gland from FVB female (Omnifix). (D) Regressing post-weaning mammary gland from FVB female (Omnifix).
(E) Hyperplastic alveolar nodule from GR female (Tellyesnicky's fixative) (D. Morris) (Han). (F) Hormone-dependent tumor or plaque from GR female (Tellyesnicky's fixative) (D. Morris) .
LEGEND:The subgross (whole mount) morphology of mammary hyperplasia. (A) Regressing mammary tree with focal MuMTV-induced hyperplastic alveolar nodule (HAN) from GR female (D. Morris). (B) Hyperplastic mammary tree from int-2 transgenic FVB mouse (D. Ornitz). (C) Lactating mammary gland from non-transgenic FVB female (M. Webster/Wm. Muller). (D) Hyperplastic mammary tree from virgin TGF transgenic FVB mouse (M. Webster/Wm. Muller). (E) Hyerplastic mammary tree from virgin Polyoma Virus middle T transgenic FVB mouse. Note multiple focal dysplasia (Wm. Muller). (F) Hyperplastic mammary tree from src 527 transgenic FVB mouse. Note focal dysplasia (M. Webster/Wm. Muller).
LEGEND:The histopathology of mammary tumors (A) MuMTV-induced Dunn Type A mammary tumor with acinar pattern in GR mouse (Tellyesnicky's fixative) (D. Morris). (B) MuMTV-induced Dunn Type B mammary tumor with mixed cord-like and cystic patterns in GR mouse (Tellyesnicky's fixative ) (D. Morris). (C) Nodular carcinoma, intermediate cell type, from FVB mouse with neu transgene (Wm. Muller)(formalin fix). (D) Papillary transitional carcinoma, small cell type, from FVB mouse with ras transgene (Omnifix) (P. Leder). (E) Papillary carcinoma with sclerosis from FVB mouse with PyV-middle T transgene (formalin fix) (Wm. Muller). (F) Papillary carcinoma from mouse with FVB int-2 transgene (Omnifix)(P.Leder). (E) Papillary carcinoma with sclerosis from FVB mouse with PyV-middle T transgene (formalin fix) (Wm. Muller). (F) Papillary carcinoma from mouse with FVB int-2 transgene (Omnifix) (P.Leder/F.Lee).
LEGEND:The histopathology of mammary adenocarcinomas. (A) Adenosquamous carcinoma from FVB mouse with cyclin-D1 transgene (formalin fix) (E. Schmidt). (B) Adenocarcinoma, large cell type, from FVB mouse with myc transgene (Omnifix)(P.Leder). (C) Adenocarcinoma, tubular, from FVB mouse with TGF transgene (formalin fix) (M.Webster). (D) Adenocarcinoma, small acinar type, from mouse with int-1 transgene (formalin fix) (R.C. Guzmann). (E) Scirrhous carcinoma from FVB mouse with src transgene (formalin fix) (M. Webster).(F) High magnification of the ras (r), neu (n), and myc (m) tumors showing differences in nuclear detail (Omnifix)(Leder).
MT TUMORS