13. Shen, MM; Skoda, RC; Cardiff, RD; Campos-Torres, J; Leder, P; Ornitz, DM. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. Embo Journal, 1994 Mar 15, 13(6):1375-85. (ABSTRACT)(ILLUSTRATIONS)(UI: 94185644);

LEGEND:
Figure 3 Representative photomicrographs of hematoxylin and eosin-stained paraffin sections of tissues from LIF transgenic mice. (A) Photomicrograph of a lung, showing the dense, dark perivascular lymphoid infiltrates (arrows) and gross congestion of the alveoli (95x)(B) High magnification view of an area of a spleen with increased megakaryocytes and immature cells (240x).(C) High magnification of an area of a mesenteric lymph node, illustrating the medullary plasmacytosis with numerous intracytoplasmic inclusions (Russell bodies) (arrows) characteristic of the LIF transgenic mice (380x). (D) Photomicrograph of a liver, demonstrating several small areas of extramedullary hematopoiesis seen as dense, darkly staining perivascular zones (arrows) (95x). (E)Two glomeruli from a transgenic kidney. Both glomeruli are involved with a membrano-proliferative process. The larger glomerulus is almost completely obliterated by the hyaline material. Note also that the tubules are atrophic (240 x). (F) Low power view of a thymus. Note the loss of cortex and the appearance of follicles (dark staining areas) (38x).

LEGEND:
Figure 4 Immunohistochemical analysis of cytokeratin (Panels A and B)and B220 (C and D)mice. Paraffin sections of the thymus were stained using the immunoperoxidase technique with polyclonal anti-keratin and monoclonal anti-B220 antibodies. Sections were counter-stained with hematoxylin to demonstrate nuclei. Note that the keratin is distributed in epithelial cells forming a diffuse network in the normal thymus. (A), but that the keratin-expressing cells from dark-staining aggregates around follicles or medullary clusters in the LIF transgenic thymus (B), White only a small number of B lymphocytes is found scattered throughout the wild type thymus (C), there are apparent follicles in the transgenic thymus (D).
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