12. Guy, CT; Muthuswamy, SK; Cardiff, RD; Soriano, P; Muller, WJ. Activation of the c-Src
tyrosine kinase is required for the induction of mammary tumors in transgenic mice.
Genes and Development, 1994 Jan, 8(1):23-32. (ABSTRACT)(ILLUSTRATIONS)(UI: 94116856);
LEGEND:Histopathology of the MMTV/PyV middle T antigen mice carrying possessing disrupted c-src alleles. A panel of photomicrographs shows the appearance of hematoxylin-stained whole-mount (left: A,C,E, at 4.9x) and hematoxylin and eosin-stained microscopic section (right: B,D,F at 48.6x) of virgin female FVB (A,B), MT(+/-);c-src(+/-)(MT#7698 at 75 days of age) (C,D) and MT(+/-);c-src(-/-)transgenic animal (MT#7832 at 140 days of age) (E,F). Note the slender, non-branching ducts of the wild-type animal, the proliferative multilayered structures in the MT#7698 animal, and the dilated complex ducts lined by a single epithelial layer in the MT#7832 animal.
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Last Updated: November 06, 1996
LEGEND:Histopathology of the MMTV/PyV middle T antigen mice carrying possessing disrupted c-src alleles. A panel of photomicrographs shows the appearance of hematoxylin-stained whole-mount (left: A,C,E, at 4.9x) and hematoxylin and eosin-stained microscopic section (right: B,D,F at 48.6x) of virgin female FVB (A,B), MT(+/-);c-src(+/-)(MT#7698 at 75 days of age) (C,D) and MT(+/-);c-src(-/-)transgenic animal (MT#7832 at 140 days of age) (E,F). Note the slender, non-branching ducts of the wild-type animal, the proliferative multilayered structures in the MT#7698 animal, and the dilated complex ducts lined by a single epithelial layer in the MT#7832 animal.
MT TUMORS