11. Cardiff, RD; Leder, A; Kuo, A; Pattengale, PK; Leder, P. Multiple tumor types appear in a transgenic mouse with the ras oncogene. American Journal of Pathology, 1993 Apr, 142(4):1199-207. (ABSTRACT)(ILLUSTRATIONS)(UI: 93235948);

LEGEND:
Figure 2 A: Photomicrograph illustrating a low-power appearance of an epidermal lesion that forms a crater with a central kertinaceous core and base of a pushing squamous cell margin (x 35). B: Photomicrograph illustrating a high-power view of an invasive squamous cell carcinoma arising from the epidermis of a TPA-treated mouse (x 220).

LEGEND:
Figure 3 A: Photomicrograph showing a mass arising in the jaw. Note the columnar epithelium and acellular eosinophilic ground substance formed between the epithelium and the fibrous stroma (x 220). B: Photomicrograph of a spindle cell lesion arising in the jaw. Note the erosion of the bone and the neoplastic stellate spindle cells laying in a myxoid stroma (x 220).

LEGEND:
Figure 4 A: Photomicrograph of a salivary cyst. Note the cystic space filled with kertinaceous debris and lined by a well-differentiated stratified squamous epithelium remnants of salivary gland are trapped in a dense fibrous stroma (x 35). B: Photomicrograph of a mammary tumor. The tumor is composed of small, rather uniform, cells with red cytoplasm oriented around a central fibrovascular stalk (x 220).

LEGEND:
Figure 5 A: Photomicrograph of a spindle cell tumor arising beneath a squamous papilloma. Note the interdigitating, herringbone pattern formed by the fusiform cells. Many of the small round cells are granulocytes found in association with these tumors (x 220). B: Photomicrograph of another dermal tumor found beneath a papilloma. Note the fragment of squamous epithelium at one edge of the field. This tumor has many multi-nucleated tumor giant cells. Note also the infiltrate of smaller granulocytes (x 220). C: Photomicrograph of the spleen of the same animal illustrated in (B). Note that the architecture is disrupted by numerous fibrous bands and an infiltrate of immature cells with scattered granulocytes and one megakaryocyte (X 220). D: Photomicrograph of the liver of the same animal illustrated in (B) and (C). Note that the liver is infiltrated with immature cells with scattered granulocytes laying in a fibrous stroma (x 220).
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