Abstract: The effect of mammary gland-specific expression of the polyomavirus middle T antigen
was examined by establishing lines of transgenic mice that carry the middle T oncogene under the
transcriptional control of the mouse mammary tumor virus promoter/enhancer. By contrast to most
transgenic strains carrying activated oncogenes, expression of polyomavirus middle T antigen
resulted in the widespread transformation of the mammary epithelium and the rapid production of
multifocal mammary adenocarcinomas. Interestingly, the majority of the tumor-bearing transgenic
mice developed secondary metastatic tumors in the lung. Taken together, these results suggest that
middle T antigen acts as a potent oncogene in the mammary epithelium and that cells that express it
possess an enhanced metastatic potential.
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Last Updated: November 06, 1996
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MT TUMORS